Biosingularity

First synthetic biology company is launched

Posted on: January 1, 2006

Synthetic Genomics, Inc., a company founded by the genome sequencing pioneer Dr. J. Craig Venter, is developing new scientific processes to enable industry to design and test desired genetic modifications. Using the genome as a bio-factory, a custom designed, modular “cassette” system will be developed so that the organism executes specific molecular functions. Synthetically produced organisms with reduced or reoriented metabolic needs will enable new, powerful, and more direct methods of bio-engineered industrial production.

According to Dr. Venter: “Work in creating a synthetic chromosome/genome will give us a better understanding of basic cellular processes. Genome composition, regulatory circuits, signaling pathways and numerous other aspects of organism gene and protein function will be better understood through construction of a synthetic genome. Not only will this basic research lead to better understanding of these pathways and components in the particular organisms, but also better understanding of human biology. The ability to construct synthetic genomes may lead to extraordinary advances in our ability to engineer microorganisms for many vital energy and environmental purposes.”

This is a very exciting new step towards biosingularity. Dr. Venter is a true visionary who has been relentlessly pushing the technology to decode the complex program of biological systems.

synthetic genomics.jpg

Synthetic genomics: a new era in research

In the last two decades the field of genomics has undergone a revolution. Scientific discoveries have come at a dazzling pace. These breakthroughs were made possible by advances in the underlying enabling technologies such as high-throughput DNA sequencing, high-performance computing, and bioinformatics. Many of these advances are directly attributable to the innovation of Dr. Venter and his teams. With the genomes of more than 300 organisms and millions of newly discovered genes readily available, genes now have the potential to be the design components of the future world economy.

Synthetic Genomics, Inc. seeks to lead the world in its ability to design, synthesize and assemble specifically engineered cell level bio-factories. The ability to make extensive changes to the DNA of a chromosome, assemble it, and insert it into an organism is in its infancy, and the capability to assemble chromosome length strands of DNA will be key to the success of the company. Synthetic Genomics, Inc. is developing new scientific processes to enable industry to design and test desired genetic modifications. Using the genome as a bio-factory, a custom designed, modular “cassette” system will be developed so that the organism executes specific molecular functions. Synthetically produced organisms with reduced or reoriented metabolic needs will enable new, powerful, and more direct methods of bio-engineered industrial production. After designing and producing a synthetic chromosome, the team plans to develop a proof of concept in either of two bio-energy applications—hydrogen or ethanol. We believe that the synthetic chromosome, and eventually a synthetic cell, will become an integral tool for the energy industry.

The science of synthetic genomics

The initial step for the Company will be to develop a minimal genome that can provide an operating system for biologically-based software. Work has been ongoing at Synthetic Genomics, Inc. in conjunction with the Venter Institute, to remove genes from simple organisms to identify the minimum set of genes necessary for an organism to survive in a controlled environment. Synthetic Genomics, Inc. intends to synthesize the proposed minimal genome, add the desired biological capabilities, and insert it into an environment that allows metabolic activity and replication – the creation of a synthetic cell.

Source: Synthetic Genomics, Inc.

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8 Responses to "First synthetic biology company is launched"

This is the nuts and bolts level of genomics. This is where real learning begins. Bill Joy was wrong to worry before. Now is the time for Bill Joy to worry.

Hey, Isn’t the first company in Synthetic Biology ‘Codon Devices’??

Codon Devices and Synthetic Genomics together are the first companies advertising themselves with a strict focus on synthetic biology. Both publicly announced their formation in June of this year (Codon Devices was first by a few weeks).

Each is also initially developing DNA synthesis technologies to support in-house research and research done in academic labs. This technology surpasses existing methods in that it will allow creation of kilobase- to megabase- length genetic sequences. From there, the companies both talk about creating engineered cells that revolve around the interchangeable parts idea.

For reference, Codon Devices was founded by some of the leading members of the academic community, including Jay Keasling of Berkeley and Drew Endy of MIT. Drew is known for his work on BioBricks, an opensource parts-based approach to synthetic biology.

Thanks for sharing! Don’t forget to attribute the second half of this article to the Synthetic Genomics website. Its verbatim from their about page!

Thanks for the comment and pointing out Codon devices. I had heard of them several months ago but then their web site became inaccessible for a while, I assumed they may have closed down. Looks like they are back in business.

I will post a separate blogs on Codon Devices and Biobricks.

Also thanks for reminding me to add the source of the article, which is added now.

hey,this is a first step in revolutionizing the field of synthetic bilogy

[...] Genomics and yes, they are also a part of bio.org. The founder of the company is none other than Dr. Craig Venter. Notice how the author of that article, a microbiologist for NYU, is ecstatic about the creation of [...]

Another approach to the creation of synthetic life. We feel that we are close with our apparatus. See Youtube video:

..with accompanying photographs in a Facebook album:

http://www.facebook.com/album.php?aid=133113&id=1195846946&l=0977042d59

I want to know which year the minigenome developed by Honorouble Dr. J. Craig Venter.

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