Biosingularity

Alpha Lipoic acid explored as an anti-aging compound

Posted on: May 19, 2007

Researchers said today they have identified the mechanism of action of lipoic acid, a remarkable compound that in animal experiments appears to slow down the process of aging, improve blood flow, enhance immune function and perform many other functions.

The findings, discussed at the “Diet and Optimum Health” conference sponsored by the Linus Pauling Institute at Oregon State University, shed light on how this micronutrient might perform such a wide range of beneficial functions.

“The evidence suggests that lipoic acid is actually a low-level stressor that turns on the basic cellular defenses of the body, including some of those that naturally decline with age,” said Tory Hagen, an LPI researcher and associate professor of biochemistry and biophysics at OSU. “In particular, it tends to restore levels of glutathione, a protective antioxidant and detoxification compound, to those of a young animal. It also acts as a strong anti-inflammatory agent, which is relevant to many degenerative diseases.”

Researchers at LPI are studying vitamins, dietary approaches and micronutrients that may be implicated in the aging or degenerative disease process, and say that lipoic acid appears to be one of those with the most compelling promise. It’s normally found at low levels in green leafy vegetables, but can also be taken as a supplement.

According to Hagen, research on the natural processes of aging, and steps that could slow it or improve health until near the end of life, are of growing importance.

“We’re coming into the middle of an aging epidemic in the country,” he said. “In a short time more than 70 million Americans will be over 65. This is partly because of the Baby Boom, but also people are living longer, being saved with antibiotics and other medical treatments. In any case, it will be an unprecedented number of elderly people in this nation.”

The goal of LPI research, Hagen said, is to address issues of “healthspan,” not just lifespan – meaning the ability to live a long life with comparatively good health and vigor, free of degenerative disease, until very near death. The best mechanisms to accomplish that, scientists say, have everything to do with diet, exercise, healthy lifestyle habits and micronutrient intake.

At the moment, Hagen said, that’s not the way things appear to be headed – diabetes is skyrocketing, about 50 percent of people over 65 have high blood pressure, heart disease often leads to permanent disability, and almost half of the elderly people in America have malnutrition that is easily preventable.

No single intervention can address all of these issues, Hagen said, but one that scientists keep coming back to is lipoic acid.

“Our studies have shown that mice supplemented with lipoic acid have a cognitive ability, behavior, and genetic expression of almost 100 detoxification and antioxidant genes that are comparable to that of young animals,” Hagen said. “They aren’t just living longer, they are living better – and that’s the goal we’re after.”

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What the OSU researchers now believe is that the role of lipoic acid is not so much a direct one to benefit cells, but rather an indirect aid that “kick starts” declining function in cells and helps them recover the functions that came more easily and naturally in young animals.

In various effects, lipoic acid appears to help restore a cellular “signaling” process that tends to break down in older blood vessels. It reduces mitochondrial decay in cells, which is closely linked to the symptoms of aging. With age, glutathione levels naturally decline, making older animals more susceptible to both free radicals and other environmental toxins – but lipoic acid can restore glutathione function to near normal. And the expression and function of other genes seems to come back to life.

“We never really expected such a surprising range of benefits from one compound,” Hagen said. “This is really unprecedented, and we’re pretty excited about it.”

Many other presentations have been made at this conference on the role of diet, lifestyle and micronutrients in health and degenerative disease, including cancer, heart disease, neurological diseases and aging.

Source: Oregon State University

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42 Responses to "Alpha Lipoic acid explored as an anti-aging compound"

I follow many life extension materials including the KurzweilAI weekday offerings. I am very happy to learn of the potential of Alpha Lipoic acid as an aide to meaningful life extension. I shall send this article along to my pen friend group through IPF, an international pen friend group devoted to spreading peace and understanding throughout the world, one-on- one. ADH

great article. please put me on your mailing list.

How much Alpha Lipoic Acid must I take every day to reverse my aging? What can I take to make my hair it’s natural color again and eliminate the gray?

Can you tell me what foods naturally contain higher levels of alpha Lipoic Acid?

Great article but need specifics of dosage. I realize these are animal studies so I guess human trials will be next. I have been aware of the claims for alpha lipoic for some time but will eagerly anticipate the results of human studies.

[...] Alpha Lipoic acid explored as an anti-aging compound Researchers said today they have identified the mechanism of action of lipoic acid, a remarkable compound that in […] [...]

how can i get lipoic acid and what dosage do i take?

Dietary Sources of Alpha-Lipoic Acid

Good food sources of alpha-lipoic acid include spinach, broccoli, beef, yeast (particularly Brewer’s yeast), and certain organ meats (such as the kidney and heart).

University of Maryland Medical Center, retrieved May 24, 2007 from http://www.umm.edu/altmed/articles/alpha-lipoic-000285.htm

I have been taking YoungAgain brand of ALA/L-Carnitine for almost 2 years in their product called “lifespan extension complex” They sometimes have good sales.

Both my husband and I take 400mg of ALA in the AM with 1000mg Acetly L Carnitine in the same pill and then in the evening we take half that dose. This is what our doctor recommends.

Remember it’s the R form of ALA, R-Lipoic acid, which is the most beneficial. Many supplement stockists only sell the inferior Alpha Lipoic Acid.

I am confused over the R LIpoic, Apha Lipoic and just plain Lipoic, I I believe that Alpha and lipoic are the same??

Can you clarify,

thanks,

I also wonder if some of the benefits of ALA have to do with its chelating actions.

Alpha Lipoic Acid is available over the counter at most drugstores. IIRC the recommended dose is 200 mg. I bought it at Walgreen’s.

Very informative and interesting article. I personally first heard of teh potential of alpha lipoic acid in Dr. Perricone’s anti-aging book. I have tried to incorporate it in my diet where I can and I look for it in various supplements.

Thanks a lot for providing these useful bits of information and especially about lipoic acid. Really informative and interesting.

I never knew lipoic acid plays a great rule in the anti aging compound. Thanks for providing a great information

Everybody is aging. But with the professional anti-aging solutions and resources provided in this website, you will certainly be able to slow down the tick of your biological clock!

This is really interesting! But it does make me wonder if we can really slow down aging. We are all getting older all the time. I think what we are really doing is looking better with age then what we would normally. But I’m not sure if we are actually going to live longer with this sort of thing.

almost taken my doctors words of advice for taking statins for cholesterol, metaphosae for pre-diabetes, and something for borderline high BP, I turned to alpha Lipoic acid and cinnamon..recently trying acai berry extract capsules…both first 2 problems are rectified and BP is starting to come down too….Im weaning off statins which gave me all kinds of side effects

I urge everyone to get the book “The Antioxident Miracle”, Written by Lester Packer, director of the Packer Lab at the University Of California at Berkeley. This man is in his 70’s, and has spent his entire life researching antioxidents, he recommends what supplements to take, lipoic acid is one of them. He recommends taking 50mg in the am and 50mg in the pm. I urge everyone to get a copy of this book if you are interested in slowing down the aging process, or just living a healthy lifestyle. I have ordered several of these books for friends, you can find them on Ebay and Amazon, look under new and used on Amazon……I love this book…….Vitamin e and the vitamin e complex is high on his list of supplements….

A follow up to the above post….When you buy supplements, DON’T BUY SYNTHETIC SUPPLEMENTS, 90-95 of all vitamins sold is synthetic, and most do absolutely no good…Always buy the natural….I love eating healthy and taking good supplements, 65 years old and feel great…I feel like I am 25….I have only been on this lifestyle for 3 years, I couldn’t believe the difference in just a few weeks when I started my change in diet and lifestye……

I take all the vitamins the “Antioxident Miracle” book recommends, I also take Natures Alive Whole Food Multi-vitamin…When something is working for you, you feel like trying to help the world…….I feel great!.

A little tip on vitamin e, and how to tell the difference in vitamin e, on the back of the bottle synthetic vitamin e will read dl tocopherol, the natural vitamin e will read d tocopherol, they try to fool you and print it in small letters…..

I was watching the program by Dr, Pericone. He highly recommends it. He mentioned it can also be used topically. What information do you have on that?

Nice to know…the value of lipoic acid,,,,,,thanks
suman

I agree with your post. I truly believe that with the help of modern science and technology, having a flawless skin is still possible today despite the environment damages the skin endures. Most experts agree that people can minimize premature aging of skin by arming themselves with knowledge about the aging process, its causes, and look for possible natural solutions like going back to healthy living by doing regular exercise, having balanced diet and developing a healthy lifestyle.

Very nice posting, informative and useful for me. Thanks for sharing.

[...] as the result of experiments with mice. As reported in May 2007 by Showcrash in his blog Biosingularity, researchers at the Linus Pauling Instiute at Oregon State University identified the mechanism of [...]

Free radicals are one of the major causes of aging, however with the use of alpha lipoic acid and other natural sources of anti oxidants we can slow or prevent many of the signs of aging.

I think is easier to prevent the signs of aging by eating the right nutrients, than trying to reverse the effects of aging. Thankyou for your informative article keep us informed.

There are many things that cause premature aging. Free radicals are definitely key culprits. The problem with people is that they don’t know how much damage they cause.

Furthermore, they don’t know how bad prepackaged food really is. The best thing to do in an anti-aging regime is to eat well and exercise.

I am constantly researching ways to prevent premature aging and let my readers know about it in layman’s terms. This is yet another interesting method in anti aging.

Thanks for the info.

So glad to see more research being done like this. I do recommend this to some of my patients.

just stopping by to say hey :)

Higher dosages can cause problems: http://www.raysahelian.com/lipoic.html

Just looking around for information on specific anti aging products and methodology; I think it’s important that people are aware of all the different methods that they can use to revitalise their skin and their current look.

Your take on alpha lipoic acid is absolutely informative! Thanks!

I truly believe that with the help of modern science and technology, having a flawless skin is still possible today despite the environment damages the skin endures. Most experts agree that people can minimize premature aging of skin by arming themselves with knowledge about the aging process, its causes, and look for possible natural solutions like going back to healthy living by doing regular exercise, having balanced diet and developing a healthy lifestyle.

Have been taking alpha lipoic acid 200mg in combination with 400mg acetyl l carnitine for two three years per (Dr. ?) Ames (Caltech???).
I truly think its the real mccoy. I am 78/79 and have no aches, pains etc and take no prescription drugs. Its available in combination at Wal-Mart.

Im not surprised by the results of their research. I’ve personally had a lifetime of horrific health problems, and at 31 approaching age 32, Ive found that Alpha lipoic acid supplements have suppressed if not completely gotten rid of many of my health problems. I’ve had chronic Rosacea as well as well as chrons disease for several years, with the Rosacea being quite virulent at times. Ive been taking Alpha Lipoic Acid for 3 months now and I can honestly say that atleast 80% of the inflammation associated with my Rosacea has completely dimished. Infact sometimes the inflammation is completely suppressed and you cannot even tell I ever had Rosacea at all! Not only that but the Alpha Lipoc Acid seems to have healed up scars from a car accident I had several years ago and even gotten rid of sundamage on my face that simply healed up! Also, my chrons is now livable and manageable. My stomach feels great these days, with no swelling, vomiting, or any other adverse reactions I used to have. After developing systemic Autoimmune problems over several years, even at one point being completely crippled from it, Lipoic Acid not only saved my life, but made it once more livable again. I dont think that Lipoic Acid “could be used to treat degenerative diseases, I think it “Should” be used to treat degenerative diseases!

[...] Source: Biosingularity. Posted in: Uncategorized ← Conspiracy Culture Goes Commercial At The Superbowl | Disinformation LikeBe the first to like this post. Be the first to start a conversation [...]

Alpha Lipoic Acid is a very powerful chelator of heavy metals, most notably Mercury.The life extension properties of ALA are likely due to its chelation effect, with the implication that heavy metal accumulation is a significant cause of aging.

More information is at:

http://www.noamalgam.com

Because ALA is such a powerful chelator, it should not be taken for any other application. The chelation process is a fairly precise one (once every four hours, day AND night, three days per week), one should check out the above website for more details prior to using ALA.

I have chelated with ALA for nearly 4 years and have found it to be rather profound, in the positive sense.

I give my Arabian mare who has endocrine and metabolic issues Alpha Lipoic Acid as an ant-oxidant. I get it from Platinum Performance. She has a pituitary adenoma that was caused by oxidative damage to dopamine producing cells in her hypothalamus. I do a lot of other things for here as well–low carb diet and pergolide tx. But this is part of the mix. The veterinary nutritionist who suggested it trained at the Linus Pauling Institute.

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