A new target for cancer drugs
Posted November 10, 2010on:
Suppressing cancer cells’ ability to cope with damage to their DNA could enhance dramatically the effectiveness of chemotherapy drugs such as cisplatin, according to a new pair of papers from MIT biologists.
In studies of mice, the researchers found that slowing down a specific system for tolerating DNA damage in cancer cells not only prolonged the lives of the mice, but also prevented relapsed tumors from becoming resistant to chemotherapy, and made tumors much less likely to spread to other parts of the body.
When DNA is damaged, enzymes repair it. MIT researchers have shown that overactivity of a certain DNA repair enzyme can help cancer cells survive chemotherapy