Biosingularity

Novartis Compound Spurs Cartilage in Arthritic Mice

Posted on: April 10, 2012

Scientists at Novartis AG (NOVN) have discovered a compound that spurred cartilage growth from stem cells to fix damaged joints of mice, a finding that may point to a novel therapy for the arthritis that afflicts most elderly.

Researchers tested 22,000 drug-like molecules using a robotic screen, applying each one to bone marrow stem cells in tiny laboratory dishes. One compound, dubbed kartogenin, promoted the development of chondrocytes, cells that become cartilage, according to the report in the journal Science.

Researchers injected kartogenin into the damaged knee joints of mice, which prompted cartilage regeneration, improved symptoms and lowered levels of proteins and collagen fragments linked to damaged joints. The results suggest a unique, though early-stage, way to regulate cartilage and possibly repair some of the damage from osteoarthritis, the breakdown of cartilage that leads to joint failure, the researchers said.

via Novartis Compound Spurs Cartilage in Arthritic Mice – Bloomberg.

About these ads

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 823 other followers

Follow me on Twitter

Medical Professional Database Award

 Doctor

Visitors Now

who's online

Blog Stats

  • 1,395,405 hits

Categories

Top Rated

Flickr Photos

Early Bird v. Worm

THe Narrows

No Delays

Glasswinged Butterfly

NEOPRIME

Storming the Hardknott Pass

Return to a Tree by a River

Happy Easter from Blavand Beach

Backwater V

.........abril

More Photos

Maps

Networked blogs

Follow

Get every new post delivered to your Inbox.

Join 823 other followers

%d bloggers like this: