Biosingularity

How Staph Toxin Disables the Immune System

Posted on: October 20, 2013

Scientists at the NYU Langone Medical Center report the discovery of a novel mechanism by which Staphylococcus aureus bacteria attack and kill off immune cells. They say their findings “Staphylococcus aureus Leukotoxin ED Targets the Chemokine Receptors CXCR1 and CXCR2 to Kill Leukocytes and Promote Infection”, published today in the journal Cell Host & Microbe, explain a critical survival tactic of a pathogen that causes more skin and heart infections than any other microbe, and kills more than 100,000 Americans every year.

“The Staphylococcus aureus leukotoxin ED LukED is a pore-forming toxin required for the lethality associated with bacteremia in murine models,” wrote the researchers. “LukED targets the chemokine receptor CCR5 to kill T lymphocytes, macrophages, and dendritic cells. LukED also kills CCR5-deficient cells like neutrophils, suggesting the existence of additional cellular receptors. Here we identify the chemokine receptors CXCR1 and CXCR2 as the targets of LukED on neutrophils.”

via GEN | News Highlights:How Staph Toxin Disables the Immune System.

About these ads

1 Response to "How Staph Toxin Disables the Immune System"

Derya, this is an interesting post. I don’t get Cell Host & Microbe. Can you please expand this post a little bit more and tell us more about the findings in this paper?

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 937 other followers

Follow me on Twitter

Medical Professional Database Award

 Doctor

Visitors Now

who's online

Blog Stats

  • 1,410,174 hits

Categories

Top Rated

Flickr Photos

Beech Mist 2

dusk

In Flight

Inde du nord 2014: vieil homme à Manali (Himachal Pradesh)

Winter Reflections

thanks

Disappearing

Best Friends

36

gray-waisted skimmer

More Photos

Maps

Networked blogs

Follow

Get every new post delivered to your Inbox.

Join 937 other followers

%d bloggers like this: