Biosingularity

Archive for the ‘Biotech’ Category

The GelSpray Liquid Bandage is a major advance in the management and care of combat casualty and civilian wounds. Much like epoxy is dispensed in household kits, the dressing is applied with a dual syringe that releases two polymer ingredients. These polymers react rapidly upon mixing to form a gel-based dressing that frontline combat soldiers can apply to their own wounds. The dressing conforms to the wound geometry, adheres to intact skin but not directly to the injured tissue, and resists abrasion.n.2-8-08-spray-bandages-cr.jpg  Read the rest of this entry »

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A team of 17 researchers at the J. Craig Venter Institute (JCVI) has created the largest man-made DNA structure by synthesizing and assembling the 582,970 base pair genome of a bacterium, Mycoplasma genitalium JCVI-1.0. This work, published online today in the journal Science by Dan Gibson, Ph.D., et al, is the second of three key steps toward the team’s goal of creating a fully synthetic organism. In the next step, which is ongoing at the JCVI, the team will attempt to create a living bacterial cell based entirely on the synthetically made genome.
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A new imaging technique developed at MIT has allowed scientists to create the first 3D images of a living cell, using a method similar to the X-ray CT scans doctors use to see inside the body.

The technique, described in a paper published in the Aug. 12 online edition of Nature Methods, could be used to produce the most detailed images yet of what goes on inside a living cell without the help of fluorescent markers or other externally added contrast agents, said Michael Feld, director of MIT’s George R. Harrison Spectroscopy Laboratory and a professor of physics.

 Images of a cervical cancer cell Read the rest of this entry »

The ability to regenerate nerve cells in the body could reduce the effects of trauma and disease in a dramatic way. In two presentations at the NSTI Nanotech 2007 Conference, researchers describe the use of nanotechnology to enhance the regeneration of nerve cells. In the first method, developed at the University of Miami, researchers show how magnetic nanoparticles (MNPs) may be used to create mechanical tension that stimulates the growth and elongation of axons of the central nervous system neurons. The second method from the University of California, Berkeley uses aligned nanofibers containing one or more growth factors to provide a bioactive matrix where nerve cells can regrow.
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Scientists reported for the first time that hemangioblast precursor cells derived from human embryonic stem (hES) cells can be used to achieve vascular repair.

The research, which appears today online (ahead of print) in the journal Nature Methods, by Advanced Cell Technology (ACT) and its collaborators, describes an efficient method for generating large numbers of bipotential progenitors–known as hemangioblasts–from hES cells that are capable of differentiating into blood vessels, as well as into all blood and immune cell lineages.
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Research teams at Yale University and the University of Rhode Island have demonstrated a new way to target and potentially treat tumors using a short piece of protein that acts like a nanosyringe to deliver “tags” or therapy to cells, according to a report in the Proceedings of the National Academy of Sciences.

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pHLIP accumulation in a mouse breast tumor grown on the right flank of a mouse. (Credit: Engelman/Reshtnyak)
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Using a new type of drug that targets a specific genetic defect, researchers at the University of Pennsylvania School of Medicine, along with colleagues at PTC Therapeutics Inc. and the University of Massachusetts Medical School, have for the first time demonstrated restoration of muscle function in a mouse model of Duchenne’s muscular dystrophy (DMD). The research appears ahead of print in an advanced online publication of Nature.

ptc_technology.jpg
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